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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24730 | Roslin 2 bromide | Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 | FAK , p53 |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects. | |||
T6954 | PRIMA-1 | 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1 | Apoptosis , Others , Ferroptosis , Autophagy |
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53. | |||
T41068 | P53R3 | p53 | |
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferativ... | |||
T79013 | SLMP53-2 | ||
SLMP53-2 is a mutant p53 reactivator that restores the wild-type-like conformation and DNA-binding ability of mutp53-Y220C through enhanced interaction with Hsp70, thereby reinstating p53's transcriptional activity. This... |